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Training resources
The OECD Adverse Outcome Pathway (AOP) development programme is overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST). Their website (https://www.oecd.org/chemicalsafety/testing/adverse-outcome-pathways-molecular-screening-and-toxicogenomics.htm) describes the programme and contains many valuable resources, including a series of webinars. The AOP concept can also be applied as a framework to develop Integrated Approaches to Testing and Assessment (IATA) and the OECD website on IATA again contains many links to informative resources (https://www.oecd.org/chemicalsafety/risk-assessment/iata-integrated-approaches-to-testing-and-assessment.htm). The following materials have been assembled to provide information about the development and application of AOPs, ranging from introductory to more advanced and those tailored specifically for AOP reviewers and journal editors.Introductory Resources
Title |
Description |
Type |
Year |
Notes |
---|---|---|---|---|
This video describes the concept and all basic principles of an AOP. This was presented by Brigitte Landesmann (JRC) within Session 1 (Introduction to AOPs) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR. HLG-LDR and Health Canada. |
Video |
2021 |
Timestamp: 3min. Length: 27min. |
|
The Adverse Outcome Pathway Framework: The Foundation for Predictive Toxicology |
This short course is a brief, high-level (beginner) overview of the value of AOPs and their contribution to toxicology. |
Video |
2018 |
Note: Scroll down to access other videos. Length: 7min, 5min, 10min, 6min, 4min. |
Introduction to the OECD AOP Programme and Online Training course |
This video introduces the OECD AOP Programme and the Online Training course. |
Video |
2017 |
Length: 33min. |
This webinar provides a high level, strategic view of the central role of AOPs in the OECD strategy on chemicals. |
Online (self-paced) course |
2015 |
Length: 35min. |
|
Online Adverse Outcome Pathway (AOP) Wiki course: AOP History and Overview |
This training resource is an interactive video providing an overview of an AOP which describes the history of AOPs in detail. There are eight sections, spanning from toxicology, structure of AOPs, to evaluation and review of AOPs. |
Video |
2017 |
This resource reflects the status of models at the time (2017) and that there may have been scientific developments since then, particularly in the area of computational models. Length: Very long and detailed but user can set pace. |
This video provides an overview of AOPs, key events, key event relationships, and training on how to use the AOP-Wiki. |
Video |
2021 |
Length: 1h 33min. |
More Advanced Resources
Title |
Description |
Type |
Year |
Notes |
---|---|---|---|---|
Frequently Asked Questions (FAQs) on AOPs for Developers. |
This comprehensive document addresses questions raised by those unfamiliar with AOPs or their development or questions commonly raised by AOP developers and/or users. |
|
2022 |
Coming soon! |
Adverse Outcome Pathways: Development and evaluation of quantitative AOPs and examples of their application. |
This course focuses on descriptions of quantitative elements in the AOP-Wiki, links between weight of evidence evaluation and quantitation and provides examples of regulatory application. |
Continuing Education course |
2022 |
Coming soon! |
This webinar outlines past and current OECD training activities and gathered feedback on experiences in conducting and/or receiving training and views, needs and ideas for the provision of training in the future. |
Video |
2017 |
Length: 1h 31min. |
|
How much is too much? Quantitative understanding and the AOP Framework |
This video describes how to understand the relationships within an AOP in a quantitative way. |
Video |
2021 |
Timestamp: 1h 15min. Length: 30min. |
This video describes the potential applications of AOPs within the field of radioprotection, including examples of quantitative application for chemicals to address questions such as shape of the dose-response curve at low doses. |
Video |
2021 |
Timestamp: 1h 45min. Length: 33min. |
|
This presentation describes the expectations from regulators and examples of the application of pathway approaches (AOPs and mode of action) in health and environmental protection for hazardous substances. |
Video |
2021 |
Timestamp: 3min. Length: 23min. |
|
This presentation describes EFSA’s perspective on how AOPs can inform regulatory decision making and provides examples to illustrate the use/implementation of human relevant AOPs. |
Video |
2021 |
Timestamp: 28min. Length: 27min. |
|
This presentation describes how to identify knowledge gaps and research priorities in weight of evidence and systematic methodology in AOP development. Identifying Knowledge Gaps and Research Priorities. |
Video |
2021 |
Timestamp: 5min. Length: 20min. |
|
Building AOPs for Neurotoxicity: Perspective from an Academic |
This video provides an academic perspective on building AOPs, in this example, for neurotoxicity. |
Video |
2021 |
Length: 31min. |
Resources for Reviewers and Journal Editors
Title |
Description |
Type |
Year |
Notes |
---|---|---|---|---|
Guidance Document for the scientific review of Adverse Outcome Pathways |
This guidance document is a useful resource for anyone considering scientific review of AOPs. |
|
2021 |
|
This video, for AOP reviewers, describes the scientific review process, including how to assess the scientific quality of an AOP. It also introduces considerations related to assessment of the weight of evidence, as well as additional factors to take into consideration. |
Video |
2019 |
Timestamp: Length: 43min. |
|
Q&A with an AOP reviewer |
This video provides a question and answer session to address questions often posed by reviewers in AOP reviews, such as tips on reviewing the weight of evidence determinations. It provides information complementary to that in the video on Scientific Review of AOPs. |
Video |
Coming Soon! |
Coming Soon! |
Q&A with a journal editor |
This video provides a question and answer session with editors of journals which publish AOPs entered in the AOP-Wiki. |
Video |
Coming Soon! |
Coming Soon! |