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AOPs in the Wiki

OECD-endorsed AOPs

Training resources

The OECD Adverse Outcome Pathway (AOP) development programme is overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST). Their website (https://www.oecd.org/chemicalsafety/testing/adverse-outcome-pathways-molecular-screening-and-toxicogenomics.htm) describes the programme and contains many valuable resources, including a series of webinars. The AOP concept can also be applied as a framework to develop Integrated Approaches to Testing and Assessment (IATA) and the OECD website on IATA again contains many links to informative resources (https://www.oecd.org/chemicalsafety/risk-assessment/iata-integrated-approaches-to-testing-and-assessment.htm). The following materials have been assembled to provide information about the development and application of AOPs, ranging from introductory to more advanced and those tailored specifically for AOP reviewers and journal editors.

Introductory Resources

Title	Description	Type	Year	Notes
The concept and all basic principles of an AOP	This video describes the concept and all basic principles of an AOP. This was presented by Brigitte Landesmann (JRC) within Session 1 (Introduction to AOPs) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR. HLG-LDR and Health Canada.	Video	2021	Timestamp: 3min. Length: 27min.
The Adverse Outcome Pathway Framework: The Foundation for Predictive Toxicology	This short course is a brief, high-level (beginner) overview of the value of AOPs and their contribution to toxicology. Topics covered are as follows: ● The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive Tools ● The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology ● Introduction to the OECD AOP Framework ● Building, Evaluating, and Using AOPs in Safety Decisions ● Online Tools Available to Everyone, Including an Online AOP Course These videos are taken from Module 4 of the Coursera Lecture entitled Toxicology 21: Scientific Applications and presented by Kate Willett (Humane Society International).	Video	2018	Note: Scroll down to access other videos. Length: 7min, 5min, 10min, 6min, 4min.
Introduction to the OECD AOP Programme and Online Training course	This video introduces the OECD AOP Programme and the Online Training course. This was presented by Kate Willett (Humane Society International) as part of the Society for the Advancement of Adverse Outcome Pathways (SAAOP) series of training videos, presented at an ancillary meeting to the 10th World Congress on Alternatives and Animals in Science in Seattle, WA.	Video	2017	Length: 33min.
OECD work on Adverse Outcome Pathways	This webinar provides a high level, strategic view of the central role of AOPs in the OECD strategy on chemicals. This was presented by Simon Upton (OECD).	Online (self-paced) course	2015	Length: 35min.
Online Adverse Outcome Pathway (AOP) Wiki course: AOP History and Overview	This training resource is an interactive video providing an overview of an AOP which describes the history of AOPs in detail. There are eight sections, spanning from toxicology, structure of AOPs, to evaluation and review of AOPs.	Video	2017	This resource reflects the status of models at the time (2017) and that there may have been scientific developments since then, particularly in the area of computational models. Length: Very long and detailed but user can set pace.
Key Event Relationship and AOP-Wiki Training	This video provides an overview of AOPs, key events, key event relationships, and training on how to use the AOP-Wiki. This was presented by Kristie Sullivan (Physicians Committee for Responsible Medicine, PCRM), Kate Willett (Humane Society International), Stephen Edwards (RTI International) and Natalia Garcia-Reyero (Engineer Research and Development Center, US Army) as training given from the CIAO COVID project – a volunteer group of experts working on Modelling the Pathogenesis of COVID-19 Using the AOP Framework	Video	2021	Length: 1h 33min.

More Advanced Resources

Title	Description	Type	Year	Notes
Frequently Asked Questions (FAQs) on AOPs for Developers.	This comprehensive document addresses questions raised by those unfamiliar with AOPs or their development or questions commonly raised by AOP developers and/or users.	pdf	2022	Coming soon!
Adverse Outcome Pathways: Development and evaluation of quantitative AOPs and examples of their application.	This course focuses on descriptions of quantitative elements in the AOP-Wiki, links between weight of evidence evaluation and quantitation and provides examples of regulatory application. This training was presented by Mirjam Luijten (RIVM), Clemens Wittwehr (JRC), Bette Meek (University of Ottawa), Stephen Edwards (RTI International) and Andrea Terron (EFSA) and given as a Continuing Education course at the International Congress of Toxicology (ICT) conference in 2022.	Continuing Education course	2022	Introduction – Length: 8min. Mirjam Luijten (RIVM): Quantitative AOPs: Background and Principles – Length: 36min. Clemens Wittwehr (JRC): AOP Knowledge Collection and Dissemination via the AOP-Wiki: Latest Developments and Live Demo – Length: 30min. Bette Meek (University of Ottawa): Weight of Evidence Evaluation for AOPs and Link to Quantitation/Stressors – Length: 45min. Stephen Edwards (RTI International): Quantitation of AOPs and Predictive Toxicology – Length: 32min. Andrea Terron (EFSA): The AOP programme at EFSA – Case studies on development and use; qualitative and quantitative aspects – Length: 48min.
Training needs, resources and opportunities for AOPs	This webinar outlines past and current OECD training activities and gathered feedback on experiences in conducting and/or receiving training and views, needs and ideas for the provision of training in the future. This webinar was presented by Magdalini Sachana (OECD), Mirjam Luijten (RIVM), Brigitte Landesmann (JRC) and Bette Meek (University of Ottawa) as part of a series of OECD supported webinars on Adverse Outcome Pathways, presented at an ancillary meeting to the 10th World Congress on Alternatives and Animals in Science in Seattle, WA.	Video	2017	Length: 1h 31min.
How much is too much? Quantitative understanding and the AOP Framework	This video describes how to understand the relationships within an AOP in a quantitative way. This was presented by Dan Villeneuve (US EPA) within Session 1 (Introduction to AOPS) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR, HLG-LDR and Health Canada.	Video	2021	Timestamp: 1h 15min. Length: 30min.
Potential Applications of AOPs in Radioprotection	This video describes the potential applications of AOPs within the field of radioprotection, including examples of quantitative application for chemicals to address questions such as shape of the dose-response curve at low doses. This was presented by Bette Meek (University of Ottawa) within Session 1 (Introduction to AOPS) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR, HLG-LDR and Health Canada.	Video	2021	Timestamp: 1h 45min. Length: 33min.
Expectations from regulators on the use of AOP in health and environmental protection against hazardous substances	This presentation describes the expectations from regulators and examples of the application of pathway approaches (AOPs and mode of action) in health and environmental protection for hazardous substances. This was presented by Sharon Munn (JRC) within Session 2 (Use of AOP for risk assessment and risk management) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD/NEA/CRPPR/HLG-LDR and Health Canada.	Video	2021	Timestamp: 3min. Length: 23min.
EFSA perspective on how AOPs can inform regulatory decision making and examples to illustrate use/implementation of AOP-informed human relevance	This presentation describes EFSA’s perspective on how AOPs can inform regulatory decision making and provides examples to illustrate the use/implementation of human relevant AOPs. This was presented by Andrea Terron (EFSA) within Session 2 (Use of AOP for risk assessment and risk management) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR, HLG-LDR and Health Canada.	Video	2021	Timestamp: 28min. Length: 27min.
Weight of Evidence and Systematic Methodology in AOP Development: Identifying Knowledge Gaps and Research Priorities	This presentation describes how to identify knowledge gaps and research priorities in weight of evidence and systematic methodology in AOP development. Identifying Knowledge Gaps and Research Priorities. This was presented by Bette Meek (University of Ottawa) within Session 5 (Usefulness of AOP to identify knowledge gaps and define research priorities) of a workshop organised by the Institute of Radioprotection and Nuclear Safety (IRSN) under the mandate of MELODI, in collaboration with the ALLIANCE and the contribution of EURADOS, OECD, NEA, CRPPR, HLG-LDR and Health Canada.	Video	2021	Timestamp: 5min. Length: 20min.
Building AOPs for Neurotoxicity: Perspective from an Academic	This video provides an academic perspective on building AOPs, in this example, for neurotoxicity. This was presented by Prof. Dr. Ellen Fritsche, IUF – Leibniz Research Institute for Environmental Medicine.as part of the Society for the Advancement of Adverse Outcome Pathways (SAAOP) series of training videos, presented at an ancillary meeting to the 10th World Congress on Alternatives and Animals in Science in Seattle, WA.	Video	2021	Length: 31min.

Resources for Reviewers and Journal Editors

Title	Description	Type	Year	Notes
Guidance Document for the scientific review of Adverse Outcome Pathways	This guidance document is a useful resource for anyone considering scientific review of AOPs.	pdf	2021
Scientific Review of AOPs	This video, for AOP reviewers, describes the scientific review process, including how to assess the scientific quality of an AOP. It also introduces considerations related to assessment of the weight of evidence, as well as additional factors to take into consideration. Presented by Dan Villeneuve (US EPA).	Video	2019	Timestamp: 00:00 Introducing the Charge Questions 02:27 Outline 04:24 Introduction to AOPs 12:37 Principles of AOP development 17:13 Key Event Pages 22:14 Relationship pages overview 22:34 Weight of evidence – biological plausibility 27:38 Weight of evidence – empirical support 28:47 Weight of evidence – guiding questions 31:06 Quantitative understanding 34:08 AOP pages 36:58 Additional considerations when reviewing 41:13 Revisiting the charge questions Length: 43min.
Q&A with an AOP reviewer	This video provides a question and answer session to address questions often posed by reviewers in AOP reviews, such as tips on reviewing the weight of evidence determinations. It provides information complementary to that in the video on Scientific Review of AOPs. Presented by Julija Filipovska (Independent Researcher), Bette Meek (University of Ottawa)and Kristie Sullivan (PCRM).	Video	Coming Soon!	Coming Soon!
Q&A with a journal editor	This video provides a question and answer session with editors of journals which publish AOPs entered in the AOP-Wiki. Presented by Nathalie Delrue (OECD), Dan Villeneuve (US EPA), Dries Knapen (University of Antwerp), Jason O’Brien (Environment and Climate Change Canada) and Kristie Sullivan (PCRM).	Video	Coming Soon!	Coming Soon!