The AFSA Collaboration has developed this Master Class to build confidence and global capacity in the use of animal-free data in safety decision-making. These state-of-the-art scientific tools support the goal of safe and sustainable products by design, and inform robust regulatory decisions, maintaining a high standard of consumer protection, and assisting compliance with animal testing restrictions.
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The AFSA Master Class has been designed for stakeholders engaged in cosmetic and chemical safety assessment and regulation, and may be especially useful for the following:
- Product and chemical safety assessors and regulators
- Regulatory affairs and compliance specialists
- CRO/GLP laboratories
- Small and medium enterprises
- Graduate students
- Non-governmental organizations
The course content is based on the principles of next-generation risk assessment (NGRA), which is an exposure-led, hypothesis-driven risk assessment approach that integrates existing knowledge with in silico, in chemico, and in vitro approaches in a tiered framework to identify situations in which a product or ingredient may be used safely.
The individual modules correspond to various components of the risk assessment process, and address how non-animal data can be used to inform safety decisions, rather than how individual non-animal tests are performed. It is hoped that this unique resource will contribute to increased understanding, acceptance, and global capacity to implement animal-free approaches as the basis for safety decisions for cosmetic products and their ingredients.
The AFSA Master Class will be launched in phases as follows:
March 2023:
- Module 0 – Overview
- Module 1 – Problem Formulation
- Module 2 – Consumer Exposure
- Module 3 – Predictive Chemistry
- Module 4a – Exposure-based Waiving
September 2023
- Module 4b – Safety of Botanicals: History of Safe Use
November 2023
- Module 8 – Global Regulatory Landscape
January 2024
- Module 6 – Internal exposure (Dosimetry)
May 2024
- Module 5 – In vitro Assay Synthesis
Fall 2024
- Module 7 – Integration into Risk Assessment
Animal Free Safety Assessment (AFSA) Scoping Document: Resources supporting implementation of non-animal methods in consumer product safety assessment