Animal-Free Safety Assessment (AFSA)

Home_page_hero

Imagine a world without animal testing… where the safety of chemicals, cosmetics, therapeutics and other products is assured using modern, human biology-based predictive tools. Making this world a reality is the goal of the AFSA Collaboration.

hero-collins

“I predict that 10 years from now, safety testing for newly developed drugs…will be largely carried out using human biochips…This approach…will mostly replace animal testing for drug toxicity and environmental sensing, giving results that are more accurate, at lower cost and with higher throughput.”
- Francis Collins, MD, PhD
Director, U.S. National Institutes of Health, 2016

“I predict that 10 years from now, safety testing for newly developed drugs…will be largely carried out using human biochips…This approach…will mostly replace animal testing for drug toxicity and environmental sensing, giving results that are more accurate, at lower cost and with higher throughput.”

- Francis Collins, MD, PhD
Director, U.S. National Institutes of Health, 2016

Francis Collins, MD, PhD
Director, U.S. National Institutes of Health 2016

The Animal-Free Safety Assessment (AFSA) Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. Meet our members:

The Animal-Free Safety Assessment (AFSA) Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. Meet our members:

Deletion of the ATT

Get the latest from the AFSA/EFPIA multi-stakeholder workshop on accelerating global deletion of the animal-based Abnormal Toxicity Test (ATT).

LEARN MORE

Removing Obsolete Vaccine Animal Tests

It's time to say good-bye to animal tests for abnormal toxicity, target animal batch safety and pyrogenicity – worldwide.

Are You AOP Trained?

Explore our continuing education materials – your one-stop shop for online training and connecting to global Adverse Outcome Pathway development efforts.

GET STARTED

Next-Generation Risk Assessment

We’re developing a new curriculum to help companies and regulators assess cosmetic safety without any new animal data.

3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-art and future opportunities

20 Oct 2022
3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-art and future opportunities

6 Oct 2022
Regulatory acceptance and use of next-generation approaches for chemical safety assessment

13 Jul 2022
Global Regulatory Landscape

10 May 2022
Dosimetry: Internal Exposure & IVIVE

5 May 2022
Predictive Chemistry: In silico tools and read-across

26 Apr 2022

View All

The overt and hidden use of animal-derived products in alternative methods for skin sensitisation: a systematic review

Marigliani B, Sehn FP, Silva JVMA, Balottin LBL, Augusto EFP, Buehler AM

Publisher’s website

Global harmonization of vaccine testing requirements: Making elimination of the ATT and TABST a concrete global achievement

Viviani L, Halder M, Gruber M, Bruckner L, Cußler K, Sanyal G, Srinivas G, Goel S, Kaashoek M, Litthauer D, Lopes da Silva A, Sakanyan E, Aprea P, Jin H, Vandeputte J, Seidle T, Yakunin D

Publisher’s website

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution

Burgdorf T, Piersma AH, Landsiedel R, Clewell R, Kleinstreuer N, Oelgeschläger M, Desprez B, Kienhuis A, Bosh P, de Vries R, de Wit L, Seidle T, Scheel J, Schönfelder G, van Benthem J, Vinggaard AM, Eskes C, Ezendam J

Publisher’s website

> View All

Animal-Free Safety Assessment (AFSA)

Deletion of the ATT

Removing Obsolete Vaccine Animal Tests

Are You AOP Trained?

Next-Generation Risk Assessment

Latest Events

3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-art and future opportunities

3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-art and future opportunities

Regulatory acceptance and use of next-generation approaches for chemical safety assessment

Global Regulatory Landscape

Dosimetry: Internal Exposure & IVIVE

Predictive Chemistry: In silico tools and read-across

The overt and hidden use of animal-derived products in alternative methods for skin sensitisation: a systematic review

Global harmonization of vaccine testing requirements: Making elimination of the ATT and TABST a concrete global achievement

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution