Animal-Free Safety Assessment (AFSA)

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Imagine a world without animal testing… where the safety of chemicals, cosmetics, therapeutics and other products is assured using modern, human biology-based predictive tools. Making this world a reality is the goal of the AFSA Collaboration.

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“I predict that 10 years from now, safety testing for newly developed drugs…will be largely carried out using human biochips…This approach…will mostly replace animal testing for drug toxicity and environmental sensing, giving results that are more accurate, at lower cost and with higher throughput.”
- Francis Collins, MD, PhD
Director, U.S. National Institutes of Health, 2016

“I predict that 10 years from now, safety testing for newly developed drugs…will be largely carried out using human biochips…This approach…will mostly replace animal testing for drug toxicity and environmental sensing, giving results that are more accurate, at lower cost and with higher throughput.”

- Francis Collins, MD, PhD
Director, U.S. National Institutes of Health, 2016

Francis Collins, MD, PhD
Director, U.S. National Institutes of Health 2016

The Animal-Free Safety Assessment (AFSA) Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. Meet our members:

The Animal-Free Safety Assessment (AFSA) Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. Meet our members:

Deletion of the ATT

Get the latest from the AFSA/EFPIA multi-stakeholder workshop on accelerating global deletion of the animal-based Abnormal Toxicity Test (ATT).

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Removing Obsolete Vaccine Animal Tests

It's time to say good-bye to animal tests for abnormal toxicity, target animal batch safety and pyrogenicity – worldwide.

Are You AOP Trained?

Explore our continuing education materials – your one-stop shop for online training and connecting to global Adverse Outcome Pathway development efforts.

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Next-Generation Risk Assessment

We’re developing a new curriculum to help companies and regulators assess cosmetic safety without any new animal data.

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REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment

Pereira M, Macmillan DS, Willett C, Seidle T.

Publisher’s website

Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients

Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, C. Yang

Publisher’s website

Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity

Hoffmann S, Marigliani B, Akgün-Ölmez SG, Ireland D, Cruz R, Busquet F, Flick B, Lalu M, Ghandakly EC, de Vries RBM, Witters H, Wright RA, Ölmez M, Willett C, Hartung T, Stephens ML, Tsaioun KA

Publisher’s website

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Animal-Free Safety Assessment (AFSA)

Deletion of the ATT

Removing Obsolete Vaccine Animal Tests

Are You AOP Trained?

Next-Generation Risk Assessment

Latest Events

Toward implementation plans for replacement of animal testing for human vaccines

How to resolve inconclusive predictions from defined approaches for skin sensitisation in OECD Guideline No. 497

3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-art and future opportunities

REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment

Regulatory acceptance and use of next-generation approaches for chemical safety assessment

Global Regulatory Landscape

REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment

Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients

Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity