Animal-Free Safety Assessment (AFSA)


First-of-its-kind AFSA Master Class in Animal-Free Safety Assessment for Cosmetics and Cosmetic Ingredients launched
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Imagine a world without animal testing… where the safety of chemicals, cosmetics, therapeutics and other products is assured using modern, human biology-based predictive tools. Making this world a reality is the goal of the AFSA Collaboration.

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The Animal-Free Safety Assessment (AFSA) Collaboration is a unique multi-sector partnership between non-profit, corporate, and philanthropic leaders working to advance acceptance and use of animal-free safety science as a gold standard across regulatory frameworks worldwide. Meet our members: 

The Animal-Free Safety Assessment (AFSA) Collaboration brings together corporate and non-profit leaders who share the goal of accelerating a modern, species-relevant approach to safety assessment globally to better protect people and our planet, and hasten the replacement of animal testing. Meet our members:

AFSA Master Class

The AFSA Collaboration has developed this Master Class in animal-free safety assessment of cosmetics to build confidence and capacity in the use of animal-free data in safety decision-making.

Canada to phase out chemical toxicity testing on animals

The Canadian Government has passed historic amendments to the Canadian Environmental Protection Act, committing to developing a roadmap to prioritize animal-free testing methods and phase out chemical toxicity testing on animals by 2035.

Publication: Last resort requirement under REACH

Europe’s failure to uphold the legal requirement of chemical testing on animals as a “last resort” exposed in new publication.

South Korea to include recombinant Factor C in the pharmacopoeia

The synthetic alternative for the Bacterial Endotoxin Test will be added in the Korean Pharmacopoeia. Another country is recognizing the sustainable choice to move away from horseshoe crabs derived reagent.

REACHing for solutions

Watch our webinar and read our peer-reviewed paper outlining our recommendations to revise EU chemicals regulation and modernise safety assessment.

Biologicals publication: Event series on animal testing alternative for vet vaccines

In collaboration with IABS, and veterinary industry association, HelathforAnimals, we hosted an event series on the implementation and regulatory acceptance of non-animal testing for veterinary vaccines’ batch release testing.

REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment

Pereira M, Macmillan DS, Willett C, Seidle T.

Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients

Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, C. Yang

Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity

Hoffmann S, Marigliani B, Akgün-Ölmez SG, Ireland D, Cruz R, Busquet F, Flick B, Lalu M, Ghandakly EC, de Vries RBM, Witters H, Wright RA, Ölmez M, Willett C, Hartung T, Stephens ML, Tsaioun KA